| Rank | Title | Distributor | Weekend Gross |
Cumulative Gross |
Release Weeks |
Number of Theaters |
| 1 | Transformers: Revenge of the Fallen | Paramount | $112,000,000 | $201,246,000 | 1 | 4,234 |
| 2 | The Proposal | Walt Disney | $18,466,000 | $69,050,000 | 2 | 3,058 |
| 3 | The Hangover | Warner Bros. | $17,215,000 | $183,247,000 | 3 | 3,525 |
| 4 | Up | Walt Disney | $13,046,000 | $250,218,000 | 5 | 3,487 |
| 5 | My Sister's Keeper | Warner Bros. | $12,030,000 | $12,030,000 | 1 | 2,606 |
| 6 | Year One | Sony | $5,800,000 | $32,307,000 | 2 | 3,024 |
| 7 | The Taking of Pelham 123 | Sony | $5,400,000 | $53,406,000 | 3 | 2,995 |
| 8 | Star Trek | Paramount | $3,606,000 | $246,225,000 | 8 | 1,823 |
| 9 | Night at the Museum: Battle of the Smithsonian | Fox | $3,500,000 | $163,247,670 | 6 | 2,250 |
| 10 | Away We Go | Focus | $1,678,251 | $4,055,736 | 4 | 495 |
| 11 | Land of the Lost | Universal | $1,143,040 | $46,763,020 | 4 | 1,504 |
| 12 | Terminator Salvation | Warner Bros. | $1,085,000 | $121,922,000 | 6 | 1,102 |