| Rank | Title | Distributor | Weekend Gross |
Cumulative Gross |
Release Weeks |
Number of Theaters |
| 1 | Dear John | Sony | $32,400,000 | $32,400,000 | 1 | 2,969 |
| 2 | Avatar | Fox | $23,600,000 | $630,093,323 | 8 | 3,000 |
| 3 | From Paris With Love | Lionsgate | $8,120,000 | $8,120,000 | 1 | 2,722 |
| 4 | Edge of Darkness | Warner Bros. | $7,005,000 | $29,097,000 | 2 | 3,066 |
| 5 | Tooth Fairy | Fox | $6,500,000 | $34,332,973 | 3 | 3,218 |
| 6 | When in Rome | Walt Disney | $5,504,000 | $20,899,000 | 2 | 2,456 |
| 7 | The Book of Eli | Warner Bros. | $4,835,000 | $82,163,000 | 4 | 2,820 |
| 8 | Crazy Heart | Fox Searchlight | $3,650,000 | $11,187,730 | 8 | 819 |
| 9 | Legion | Sony | $3,400,000 | $34,600,000 | 3 | 2,339 |
| 10 | Sherlock Holmes | Warner Bros. | $2,630,000 | $201,579,000 | 7 | 1,805 |
| 11 | The Blind Side | Warner Bros. | $2,600,000 | $241,626,000 | 12 | 1,740 |
| 12 | Up in the Air | Paramount | $2,350,000 | $76,681,000 | 10 | 1,547 |