| Rank | Title | Distributor | Weekend Gross |
Cumulative Gross |
Release Weeks |
Number of Theaters |
| 1 | The Dark Knight | Warner Bros. | $43,800,000 | $394,887,000 | 3 | 4,266 |
| 2 | The Mummy: Tomb of the Dragon Emperor | Universal | $42,450,400 | $42,450,400 | 1 | 3,760 |
| 3 | Step Brothers | Sony | $16,300,000 | $62,966,000 | 2 | 3,094 |
| 4 | Mamma Mia! | Universal | $13,120,670 | $87,975,280 | 3 | 3,062 |
| 5 | Journey to the Center of the Earth | Warner Bros. | $6,875,000 | $73,140,000 | 4 | 2,285 |
| 6 | Swing Vote | Walt Disney | $6,300,000 | $6,300,000 | 1 | 2,213 |
| 7 | Hancock | Sony | $5,200,000 | $215,995,000 | 5 | 2,782 |
| 8 | WALL-E | Walt Disney | $4,747,000 | $204,222,000 | 6 | 2,555 |
| 9 | The X-Files: I Want to Believe | Fox | $3,425,000 | $17,060,495 | 2 | 3,185 |
| 10 | Space Chimps | Fox | $2,840,000 | $22,090,839 | 3 | 2,134 |
| 11 | Hellboy II: The Golden Army | Universal | $2,527,110 | $71,272,920 | 4 | 1,959 |
| 12 | Wanted | Universal | $1,257,475 | $131,337,590 | 6 | 895 |